Home  > Winged Treebine

Winged Treebine
Winged treebine is an ancient medicinal plant native to the hotter parts of Asia mainly in India, Africa and South America aminly in chile, and Ceylon. It mainly contain quadrangularis A, B, and C, resveratrol, piceatannol, pallidol, parthenocissin, octadecanoate, lipids and phytosterols.

Orally, Winged treebine is also used in body building supplements as an alternative to anabolic steroids. It has also been used for bone fractures, osteoporosis, scurvy, cancer, dyspepsia, hemorrhoids, peptic ulcer disease (PUD), dysmenorrhea, asthma, malaria, and pain. It is used for obesity and weight loss, diabetes, metabolic syndrome, and hyperlipidemia.

HEALING ACTIVITY:
It is known to be an ancient medical plant, with optimal healing in white tissue areas of the body ( tendons, ligaments, etc). It also helps heal fractures by increases in new bone growth, and has been shown to relieve arthritis and osteoarthritis. Modern research has shed light on its ability to speed bone healing by showing it acts as a glucocorticoid antagonist. Since anabolic/androgenic compounds are well known to act as antagonists to the glucocorticoid receptor as well as promote bone growth and fracture healing. In addition to speeding the remodeling process of the healing bone, Winged treebine also leads to a much faster increase in bone tensile strength. In clinical trials Winged treebine has led to a fracture healing time on the order of 55 to 33 percent of that of controls.

ANTIOXIDANT AND ANTI-MICROBIAL ACTIVITY:
Extracts of it were tested for antioxidant activity by b-carotene linoleic acid model and also by 1,1-diphenyl-2-picrylhydrazyl model. The ethyl acetate fraction of both fresh and dry stem extracts at a concentration of 100 ppm showed 64.8% antioxidant activity in the b-carotene linoleic acid system and 61.6% in the 1,1-diphenyl-2-picrylhydrazyl system. The ethyl acetate extract and methanol extract of both fresh and dry stems further exhibited antimicrobial activity against Gram-positive bacteria, including Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Streptococcus species. The results of the study have implications in the use of it as an antibacterial agent and more so as an antioxidant.

ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES:
In the analgesic test, it provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. It also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of it. In acute phase of inflammation it elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that it is a dual inhibitor of arachidonic acid metabolism.

SAFETY:
Studies in rats showed no toxic effects at dosages as high as 2000 mg/kg of body weight. So it is not only is effective but quite safe.

HERBAL DRUG INTERACTIONS:
Not known.

REFERENCES: